Selected Publications

Anderson, D.H., Kickhoefer, V.A., Sievers, S.A., Rome, L.H., Eisenberg, D. "Draft crystal structure of the vault shell at 9-Å resolution." PLoS Biology, 11(5):2661-70 (2007).

Goldsmith, L.E., Yu, M., Rome, L.H., Monbouquette, H.G. "Vault nanocapsule dissociation into halves triggered at low pH." Biochemistry, 46:2865-75 (2007).

Kaddis, C.S., Lomeli, S.H., Yin, S., Berhane, B., Apostol, M.I., Kickhoefer, V.A., Rome, L.H., Loo, J.A. "Sizing large proteins and protein complexes by electrospray ionization mass spectrometry and ion mobility." J. Am. Soc. Mass Spectrom. 18(7):1206-16 (2007).

Mrazek, J., Kreutmayer, S.B., Grasser, F.A., Polacek, N., Huttenhofer, A. "Subtractive hybridization identifies novel differentially expressed ncRNA species in EBV-infected human B cells." Nucleic Acids Res. 35(10):e73 (2007).

Kowalski, M.P., Dubouix-Bourandy, A., Bajmoczi, M., Golan, D.E., Zaidi, T., Coutinho-Sledge, Y.S., Gygi, M.P., Gygi, S.P., Wiemer, E.A.C., Pier, G.B. "Host resistance to lung infection mediated by major vault protein in epithelial cells." Science 317:130-132 (2007).

Yi, C., Li, S., Wang, J., Wei, N., Deng, X.W. "Affinity purification reveals the association of WD40 protein constitutive photomorphogenic 1 with the hetero-oligomeric TCP-1 chaperonin complex in mammalian cells." Int. J. Biochem. Cell Biol. 38(7): 1076-83 (2006).

Steiner, E., Holzmann, K., Pirker, C., Elbling, L., Micksche, M., Sutterlüty, H., Berger, W. "The major vault protein is responsive to and interferes with interferon-gamma-mediated STAT1 signals." J. Cell Sci. 119(Pt. 3): 459-69 (2006).

Kim, E., Lee, S., Mian, M.F., Yun, S.U., Song, M., Yi, K.S., Ryu, S.H., Suh, P.G. "Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signaling." FEBS J., 273: 793-804 (2006).

Kozlov, G., Vavelyuk, O., Minailiuc, O., Banville, D., Gehring, K., Ekiel, I. "Solution structure of a two-repeat fragment of major vault protein." J. Mol. Biol. 356: 444-52 (2006).

van Zon, A., Mossink, M.H., Houtsmuller, A.B., Schoester, M., Scheffer, G.L., Scheper, R.J., Sonneveld, P., Wiemer, E.A. "Vault mobility depends in part on microtubules and vaults can be recruited to the nuclear envelope." Exp. Cell Res. 312: 245-55 (2006).

Raval-Fernandes, S., Kickhoefer, V.A., Kitchen, C., Rome, L.H. "Increased susceptibility of vault poly(ADP-ribose) polymerase deficient mice to carcinogen-induced tumorigenesis." Cancer Res. 65(19): 8846-52 (2006).

Slesina, M., Inman, E.M., Moore, A.E., Goldhaber, J.I., Rome, L.H., Volknandt, W. "Movement of vault particles visualized by GFP-tagged major vault protein." Cell Tissue Res. 324: 403-10 (2006).

Poderycki, M.J., Kickhoefer, V.A., Kaddis, C.S., Raval-Fernandes, S., Johansson, E., Zink, J.I., Loo, J.A., Rome, L.H. "The vault exterior shell is a dynamic structure that allows incorporation of vault-associated proteins into its interior." Biochemistry, 45:12184-93 (2006).

Kickhoefer, V.A., Garcia, Y., Mikyas, Y., Johansson, E., Zhou, J.C., Raval-Fernandes, S., Minoofar, P., Zink, J.I., Dunn, B., Stewart, P.L., Rome, L.H. "Engineering of vault nanocapsules with enzymatic and fluorescent properties." Proc. Natl. Acad. Sci. USA, 102(12): 4348-52 (2005).

Poderycki, M.J., Rome, L.H., Harrington, L., Kickhoefer, V.A. "The p80 homology region of TEP1 is sufficient for its association with the telomerase and vault RNAs, and the vault particle." Nucleic Acids Res. 33(3): 893-902 (2005).

Slesina, M., Inman, E.M., Rome, L.H., Volknandt, W. "Nuclear localization of the major vault protein in U373 cells." Cell Tissue Res. 321(1): 97-104 (2005).

Yi, C., Li, S., Chen, X., Wiemer, E.A., Wang, J., Wei, N., Deng, X.W. "Major vault protein, in concert with constitutively photomorphogenic 1, negatively regulates c-Jun-mediated activator protein 1 transcription in mammalian cells." Cancer Res. 65: 5835-40 (2005).

Chung, J.H., Ginn-Pease, M.E., Eng, C. "Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault protein." Cancer Res. 65: 4108-16 (2005).

Zheng, C.L., Sumizawa, T., Che, X.F., Tsuyama, S., Furukawa, T., Haraguchi, M., Gao, H., Gotanda, T., Jueng, H.C., Murata, F., Akiyama, S. "Characterization of MVP and VPARP assembly into vault ribonucleoprotein complexes." Biochem. Biophys. Res. Commun. 326: 100-7 (2005).

Chung, J.H., Eng, C. "Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis." Cancer Res. 65: 8096-100 (2005).

Stewart, P.L., Makabi, M., Lang, J., Dickey-Sims, C., Robertson, A.J., Coffman, J.A., Suprenant, K.A. "Sea urchin vault structure, composition, and differential localization during development." BMC Dev. Biol. 5:3 (2005).

Huffman, K.E., Corey, D.R. "Major vault protein does not play a role in chemoresistance or drug localization in a non-small cell lung cancer cell line." Biochemistry, 44: 2253-61 (2005).

Mikyas, Y., Makabi, M., Raval-Fernandes, S., Harrington, L., Kickhoefer, V.A., Rome, L.H., Stewart, P.L. "Cryoelectron microscopy imaging of recombinant and tissue derived vaults: localization of the MVP N termini and VPARP." J. Mol. Biol. 344: 91-105 (2004).

Emre, N., Raval-Fernandes, S., Kickhoefer, V.A., Rome, L.H. "Analysis of MVP and VPARP promoters indicates a role for chromatin remodeling in the regulation of MVP." Biochim. Biophys. Acta. 1678: 33-46 (2004).

Liu, Y., Snow, B.E., Kickhoefer, V.A., Erdmann, N., Zhou, W., Wakeham, A., Gomez, W., Rome, L.H., Harrington, L. "Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo." Mol. Cell. Biol. 12: 5314-23 (2004).

Kolli, S., Zito, C.I., Mossink, M.H., Wiemer, E.A., Bennet, A.M. "The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling." J. Biol. Chem. 279: 29374-85 (2004).

Krull, S., Thyberg, J., Björkroth, B., Rackwitz, H.R., Cordes, V.C. "Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket." Mol. Biol. Cell, 15: 4261-77 (2004).

Stam, R.W., van den Huevel-Eibrink, M.M., den Boer, M.L., Ebus, M.E., Janka-Schaub, G.E., Allen, J.D., Pieters, R. "Multidrug resistance genes in infant acute lymphoblastic leukemia: Ara-C is not a substrate for the breast cancer resistance protein." Leukemia, 18: 78-83 (2004).

Steiner, E., Holzmann, K., Pirker, C., Elbling, L., Micksche, M., Berger, W. "SP-transcription factors are involved in basal MVP promoter activity and its stimulation by HDAC inhibitors." Biochem. Biophys. Res. Commun. 317(1): 235-243 (2004).

van Zon, A., Mossink, M.H., Schoester, M., Scheper, R.J., Sonneveld, P., Wiemer, E.A. "Efflux kinetics and intracellular distribution of danorubicin are not affected by major vault protein/lung resistance-related protein (vault) expression." Cancer Res. 64: 4887-92 (2004).

Kickhoefer, V.A., Emre, N., Stephen, A., Poderycki, M., Rome, L.H. "Identification of conserved vault RNA expression elements and a non-expressed mouse vault gene." Gene 309: 65-70 (2003).

Eichenmuller, B., Kedersha, N., Solovyeva, E., Everley, P., Lang, J., Himes, R.H., Suprenant, K.A. "Vaults bind directly to microtubules via their caps and not their barrels." Cell Motil. Cytoskeleton, 56: 225-236 (2003).

Mossink, M.H., van Zon, A., Scheper, R.J., Sonneveld, P., Wiemer, E.A. "Vaults: a ribonucleoprotein particle involved in drug resistance?" Oncogene, 22(47): 7458-67 (2003).

van Zon, A., Mossink, M.H., Scheper, R.J., Sonneveld, P., Wiemer, E.A. "The vault complex." Cell Mol. Life Sci. 60: 1828-37 (2003).

van Zon, A., Missink, M.H., Schoester, M., Houtsmuller, A.B., Scheffer, G.L., Scheper, R.J., Sonneveld, P., Wiemer, E.A. "The formation of vault-tubes: a dynamic interaction between vaults and vault PARP." J. Cell Sci. 116: 4391-400 (2003).

Mossink, M.H., de Groot, J., van Zon, A., Fränzel-Luiten, E., Schoester, M., Scheffer, G.L., Sonneveld, P., Scheper, R.J., Wiemer, E.A. "Unimpaired dendritic cell functions in MVP/LRP knockout mice." Immunology 110: 58-65 (2003).

Kickhoefer, V.A., Poderycki, M.J., Chan, E.K., Rome, L.H. "The La RNA-binding protein interacts with the vault RNA and is a vault-associated protein." J. Biol. Chem. 277(43): 41282-6 (2002).

Yu, Z., Fotouhi-Ardakani, N., Wu, L., Maoui, M., Wang, S., Banville, D., Shen, S.H. "PTEN associates with the vault particles in HeLa cells." J. Biol. Chem. 277(43): 40247-52 (2002).

Scheffer, G.L., Pijnenborg, A.C., Smit, E.F., Muller, M., Postma, D.S., Timens, W., van der Valk, P., de Vries, E.G., Scheper, R.J. "Multidrug resistance related molecules in human and murine lung." J. Clin. Pathol. 55(5): 332-39 (2002).

Scheffer, G.L., Reurs, A.W., Jutten, B., Beiboer, S.H., van Amerongen, R., Schoester, M., Wiemer, E.A. "Selection and characterisation of a phage-displayed human antibody (Fab) reactive to the lung resistance-related major vault protein." Br. J. Cancer 86(6): 954-62 (2002).

van Zon, A., Mossink, M.H., Schoester, M., Scheffer, G.L., Scheper, R.J., Sonneveld, P., Wiemer, E.A. "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly." Biochem. Biophys. Res. Commun. 291(3): 535-41 (2002).

Schoreijers, A.B., Reurs, A.W., Scheffer, G.L., Stam, A.G., de Jong, M.C., Rustemeyer, T., Wiemer, E.A., de Gruijl, T.D., Scheper, R.J. "Up-regulation of drug resistance-related vaults during dendritic cell development." J. Immunol. 168(4): 1572-8 (2002).

Mossink, M.H., van Zon, A., Fränzel-Luiten, E., Schoester, M., Kickhoefer, V.A., Scheffer, G.L., Scheper, R.J., Sonneveld, P., Wiemer, E.A. "Disruption of the murine major vault protein (MVP/LRP) gene does not induce hypersensitivity to cytostatics." Cancer Res. 62(24): 7298-304 (2002).

Hu, Y., Stephen, A.G., Cao, J., Tanzer, L.R., Slapak, C.A., Harrison, S.D., Devanaravan, V., Dantzig, A.H., Starling, J.J., Rome, L.H., Moore, R.E. "A very early induction of major vault protein is accompanied by increased drug resistance in U-937 cells." 97(2): 149-156 (2002).

Kickhoefer, V.A., Liu, Y., Kong, L.B., Snow, B.E., Stewart, P.L , Harrington, L., and Rome, L.H. "The telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle." J. Cell Biol. 152: 157-164 (2001).

Stephen, A.G., Raval-Fernandes, S., Huynh, T., Torres, M., Kickhoefer, V.A. and Rome, L.H. "Assembly of vault-like particles in insect cells expressing only the major vault protein." J. Biol. Chem. 276: 23217-23220 (2001).

Schroeijers, A.B., Scheffer, G.L., Reurs, A.W., Pijnenborg, A.C., Abbondanza, C., Wiemer, E.A., Scheper, R.J. "Detection of the Mr 110,000 lung resistance-related protein LRP/MVP with monoclonal antibodies." J. Histochem. Cytochem. 49: 1379-86 (2001).

van Zon, A., Mossink, M.H., Schoester, M., Scheffer, G.L., Scheper, R.J., Sonneveld, P., Wiemer, E.A. "Multiple human vault RNAs. Expression and association with the vault complex." J. Biol. Chem. 276: 37715-37721 (2001).

Siva, A.C., Raval-Fernandes, S., Stephen, A.G., LaFemina, M.J., Scheper, R.J., Kickhoefer, V.A., Rome, L.H. "Upregulation of vaults may be necessary but not sufficient for multidrug resistance." Int. J. Cancer 92: 195-202 (2001).

Holzmann, K., Ambrosch, I., Elbling, L., Micksche, M., Berger, W. "A small upstream open reading frame causes inhibition of human major vault protein expression from a ubiquitous mRNA splice variant." FEBS Letters, 494: 99-104 (2001).